Fructose: “Alcohol without the buzz” (Published Paper Review)
Its me again, this a review of a published paper I found out about fructose hope u learn something…..
Department of Pediatrics and Philip R. Lee Institute for Health Policy Studies.2013. “Fructose: It’s “Alcohol without the Buzz.” Univeristy of Califonia, San Francisco, CA. Accessed March 30,2013. http://www.ncbi.nlm.nih.gov/pubmed/23493539
Can a diet high in fructose leads to obesity?
Well just like there is lactose intolerance, there is also fructose intolerance where there is a deficiency the enzyme fructose-1-phosphate aldolase B which can lead to a person to be unable to consume any source of fructose else they would be hypoglycemic.
The action fructose displays on the body imitates that of ethanol which is a very unessential energy source. This paper seeks to give information on how ethanol and fructose are similar and different.
Glut5 transporter is found in the liver which metabolizes fructose. While glucose which we know when in excess is converted to glycogen by insulin, fructose however is not converted to glycogen directly. Fructose is phosphorylated without insulin to fructose-1-phosphate which is catalyzed by fructokinase. Fructose 1 phosphate then enters the glycolysis pathway which is metabolized to pyruvate which produces a large volume of acetyl-CoA which enters the Krebs cycle. Fructose goes down a lipogen pathway which triples the rate of DNL.
Ethanol is not metabolized by the glycolytic pathway however it is converted to acetaldehyde by the enzyme alcohol dehydrogenase which then is metabolized by aldehyde dehydrogenase 2 to acetic acid. The acetic acid is then converted to acetyl Co A which enters the Krebs cycle. A large consumption of ethanol produces a large amount of acetyl CoA, the ethanol is then converted to FFA’s through DNL.
Fructose verses Ethanol
When taken in small amount they will not go over the hepatic mitochondrial capacity. They both drive DNL which is insulin resistant. Fructose benefits insulin secretion like alcohol in small amounts. However they are both dependent on the doses. Fructose can cause dyslipidemia, hepatic seatosis and insulin resistance similar to ethanol. Although ethanol is manufactured by fructose fermentation, the yeast in ethanol is used for glycolysis while us humans our own body perform glycolysis for metabolizing fructose. Fructose does not have the same toxic effects as ethanol however it does have a long term chronic toxic effect on your health.